Alumis Inc., a clinical stage biopharmaceutical company, focuses on the development and commercialization of medicines for autoimmune disorders. The company's clinical asset comprises ESK-001, an allosteric tyrosine kinase 2 (TYK2) inhibitor for the treatment of plaque psoriasis and systemic lupus erythematosus; and A-005, a central nervous system-penetrant allosteric TYK2 inhibitor for neuroinflammatory and neurodegenerative diseases. It also develops interferon regulatory factor 5 (IRF5) to address immune dysfunction. The company was formerly known as Esker Therapeutics, Inc. and changed its name to Alumis Inc. in January 2022. The company was incorporated in 2021 and is headquartered in South San Francisco, California. Show more

280 East Grand Avenue, South San Francisco, CA, 94080, United States

Biotechnology

Healthcare

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Market Cap

3.448B

52 Wk Range

$2.76 - $30.60

Previous Close

$27.65

Open

$27.55

Volume

1,070,661

Day Range

$27.45 - $28.60

Enterprise Value

-35.45M

Cash

377.7M

Avg Qtr Burn

-110.9M

Insider Ownership

0.68%

Institutional Own.

74.95%

Qtr Updated

09/30/25

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Drug & Indication	Stage & Event	Catalyst Date
ESK-001 Details Moderate-to-severe plaque psoriasis	NDA Submission	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
ESK-001 Details Systemic lupus erythematosus	Phase 2b Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
A-005 Details Multiple sclerosis	Phase 2 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Lonigutamab (IGF-1R Antibody) Details Thyroid Eye Disease	Phase 1/2 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.