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Applied Therapeutics NASDAQ:APLT Applied Therapeutics is a clinical-stage biopharmaceutical company developing a pipeline of novel drug candidates against validated molecular targets in indications of high unmet medical need. The Company's lead drug candidate, AT-007, is a novel central nervous system penetrant aldose reductase inhibitor (ARI) for the treatment of Galactosemia, a rare pediatric metabolic disease. The Company initiated a pivotal Phase 1/2 clinical trial in June 2019, read out positive top-line biomarker data in adult Galactosemia patients in January 2020 and announced full data from the trial in April 2020. A pediatric Galactosemia study commenced in June 2020. The Company is also developing AT-001, a novel potent ARI that is being developed for the treatment of Diabetic Cardiomyopathy, or DbCM, a fatal fibrosis of the heart. The Company initiated a Phase 3 registrational study in DbCM in September 2019. The preclinical pipeline also includes AT-003, an ARI designed to cross through the back of the eye when dosed orally, for the treatment of diabetic retinopathy, as well as novel dual PI3k inhibitors in preclinical development for orphan oncology indications.

Location: 545 5Th Avenue, Suite 1400, New York, 10017, US | Website: www.appliedtherapeutics.com | Industry: Research and Development in Biotechnology | Sector: Professional, Scientific, and Technical Services

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52 Wk Range

$ - $

Previous Close

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Day Range

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Volume

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Avg Volume

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Enterprise Value

-15.03M

Cash

79.4M

Avg Qtr Burn

-21.08M

Short % of Float

15.00%

Insider Ownership

5.32%

Institutional Own.

88.67%

Qtr Updated

12/31/24

Drug Pipeline

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Drug & Indication	Stage & Event	Catalyst Date
Govorestat (AT-007) Details Galactosemia, Rare diseases, Rare genetic disease	NDA Resubmission	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Govorestat (AT-007) Details Sorbitol dehydrogenase deficiency	NDA Submission	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Caficrestat (AT-001) Details Hemophilia, Genetic disorder, Diabetic cardiomyopathy	Phase 3 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Govorestat (AT-007) Details Phosphomannomutase 2 deficiency , Congenital disorder of glycosylation	Phase 2 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
AT-003 Details Diabetic retinopathy	Phase 1 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
AT-104 Details Leukemia, B-cell acute lymphoblastic leukemia, T-cell lymphoma	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.