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Aptose Biosciences NASDAQ:APTO Aptose Biosciences is a clinical-stage biotechnology company committed to developing personalized therapies addressing unmet medical needs in oncology, with an initial focus on hematology. The Company's small molecule cancer therapeutics pipeline includes products designed to provide single agent efficacy and to enhance the efficacy of other anti-cancer therapies and regimens without overlapping toxicities. The Company has two clinical-stage investigational products for hematologic malignancies: CG-806, an oral, first-in-classmutation-agnostic FLT3/BTK kinase inhibitor, is in a Phase 1 trial in patients with relapsed or refractory B cell malignancies, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL) and non-Hodgkin lymphoma (NHL), who have failed or are intolerant to standard therapies, and is in a separate Phase 1 trial in patients with relapsed or refractory acute myeloid leukemia (AML); APTO-253, the only known clinical stage agent that directly targets the MYC oncogene and suppresses its expression, is in a Phase 1b clinical trial for the treatment of patients with relapsed or refractory AML or high risk myelodysplastic syndrome (MDS).

Location: 251 Consumers Rd Suite 1105, Ontario, M2J 4R3, Canada | Website: aptose.com | Industry: Biological Product (except Diagnostic) Manufacturing | Sector: Manufacturing

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52 Wk Range

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Enterprise Value

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Cash

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Avg Qtr Burn

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Short % of Float

1.05%

Insider Ownership

16.39%

Institutional Own.

16.69%

Qtr Updated

09/30/24

Drug Pipeline

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Drug & Indication	Stage & Event	Catalyst Date
Tuspetinib / Venetoclax / Azacitidine triplet Details Acute myeloid leukemia, Cancer, Leukemia	Phase 1/2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Tuspetinib mono/combo w/ Venetoclax Details Acute myeloid leukemia, Cancer, Leukemia, Relapsed/refractory acute myeloid leukemia	Phase 1/2 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Luxeptinib (CG-806) (BTK and FLT3 Inhibitor) Details Chronic lymphocytic leukemia, Non-Hodgkin lymphoma, Acute myeloid leukemia, Cancer	Phase 1/2 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
APTO-253 (MYC inhibitor) Details Acute myeloid leukemia, Cancer, Myelodysplastic syndrome	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Tuspetinib (HM43239) & luxeptinib Details Acute myeloid leukemia, B-cell malignancies, Relapsed/refractory acute myeloid leukemia	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.