Ionis Pharmaceuticals, Inc. is a prominent biopharmaceutical company headquartered in Carlsbad, California, renowned for its innovative RNA-targeted therapies that tackle severe and complex health challenges. Leveraging its proprietary antisense technology, Ionis addresses significant unmet medical needs across critical therapeutic areas, including neurological disorders, cardiovascular diseases, and oncology. The company boasts a robust pipeline of both proprietary and partnered assets, positioning itself as a leader in precision medicine and showcasing its ability to enhance patient outcomes. Ionis's steadfast commitment to research and development underpins its strategic growth potential and transformative influence within the biopharmaceutical sector. Show more

Location: 2855 GAZELLE COURT, CARLSBAD, CA, UNITED STATES, 92010, Carlsbad, CA, 92010, USA | Website: https://www.ionis.com | Industry: BIOTECHNOLOGY | Sector: HEALTHCARE

Market Cap

13.52B

52 Wk Range

$23.95 - $86.74

Previous Close

$83.48

Open

$84.85

Volume

1,996,521

Day Range

$84.18 - $86.59

Enterprise Value

12.77B

Cash

338.3M

Avg Qtr Burn

-131.4M

Insider Ownership

0.63%

Institutional Own.

Qtr Updated

09/30/25

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Drug & Indication	Stage & Event	Catalyst Date
TRYNGOLZA™ (olezarsen) Details Familial chylomicronemia syndrome	Approved Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
QALSODY™ (Tofersen) Details Amyotrophic lateral sclerosis	Approved Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
WAINUA™ Eplontersen (AKCEA-TTR-LRx) Details Transthyretin amyloidosis	Approved Quarterly sales	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
DAWNZERA™ (donidalorsen) Details Hereditary angioedema	Approved Quarterly sales	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
SPINRAZA Details Spinal muscular atrophy	Approved Quarterly sales	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
IONIS-APOCIII-LRx (Olezarsen) Details Severe hypertriglyceridemia (sHTG)	sNDA Acceptance for review	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Zilganersen (ION373) Details Alexander Disease	NDA Submission	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
ION582 Details Angelman Syndrome	Phase 3 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
IONIS-FB-LRx Details IgA nephropathy	Phase 3 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Bepirovirsen (IONIS-HBVRx) Details Hepatitis B	Phase 3 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Ulefnersen (ION363 ) Details Amyotrophic lateral sclerosis	Phase 3 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Eplontersen (AKCEA-TTR-LRx) Details Diabetic cardiomyopathy, Transthyretin amyloidosis, Transthyretin Amyloid Cardiomyopathy	Phase 3 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Pelacarsen Details Heart disease, Cardiovascular disease	Phase 3 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
ION839 / AZD2693 Details Non-alcoholic steatohepatitis	Phase 2b Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
ION224 Details Non-alcoholic steatohepatitis	Phase 2b Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
IONIS-MAPTRx (BIIB080) Details Alzheimer's disease	Phase 2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
IONIS-AGT-LRx Details Heart failure, Pulmonary hypertension	Phase 2 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Tominersen (IONIS-HTT Rx) Details Huntington's disease	Phase 2 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
IONS356 (PLP1) Details Pelizaeus-Merzbacher disease	Phase 1/2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Cimdelirsen (IONIS-GHR-LRx) Details Acromegaly	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
IONIS-FB-LRx Details Geographic atrophy	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Fesomersen (IONIS-FXI-LRx) Details Hepatitis B	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
IONIS-ENaC-2.5Rx (antisense medicine) Details Cystic fibrosis	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.