Lyell Immunopharma, Inc., a clinical-stage cell therapy company, develops chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. The company develops therapies using various approaches, such as c-Jun overexpression and NR4A3 gene knockout, to endow functional resistance to exhaustion; Epi-R to generate population of stem-like T cells with reduced exhaustion and improved proliferation and antitumor activity; CD62L positive enrichment to generate CAR T cells with enhanced antitumor activity; and Stim-R, a proprietary synthetic-cell mimetic. It is also developing IMPT-314, a dual-targeting CD19/CD20 CAR T-cell product candidate that is in Phase 1/2 clinical development for the treatment of patients with aggressive relapsed/refractory large B-cell non-Hodgkin lymphoma; and solid tumors program which is in preclinical trial targeting solid tumor indications. Lyell Immunopharma, Inc. was incorporated in 2018 and is headquartered in South San Francisco, California. Show more

Location: 201 Haskins Way, South San Francisco, CA, 94080, United States | Website: https://www.lyell.com | Industry: Biotechnology | Sector: Healthcare

Market Cap

535.8M

52 Wk Range

$7.65 - $25.74

Previous Close

$25.25

Open

$25.87

Volume

30,004

Day Range

$25.50 - $27.94

Enterprise Value

260.4M

Cash

319.6M

Avg Qtr Burn

-41.25M

Insider Ownership

27.68%

Institutional Own.

50.16%

Qtr Updated

09/30/25

Drug Pipeline

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Drug & Indication	Stage & Event	Catalyst Date
Ronde-cel (LYL314) Details B-cell lymphoma	Phase 1/2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
LYL273 (GCC CAR-T) Details Metastatic Colorectal Cancer	Phase 1 Interim update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
LYL119 Details Solid tumor/s, Cancer	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
LYL797 Details Solid tumor/s, Cancer, Non-small cell lung carcinoma, Breast cancer	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
LYL845 Details Solid tumor/s, Cancer, Colorectal cancer , Non-small cell lung carcinoma, Melanoma	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.