Protagonist Therapeutics, Inc., a biopharmaceutical company, develops peptide therapeutics for hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing Rusfertide, an injectable mimetic of hepcidin that is in phase 3 clinical trials for the treatment of polycythemia vera; Icotrokinra, an orally delivered investigational drug which is in phase 3 clinical trials indicated to block biological pathways targeted by marketed injectable antibody drugs; and PN-943, an orally delivered, gut-restricted alpha 4 beta 7 specific integrin antagonist completed a phase 2 clinical trials in patients with moderate to severe ulcerative colitis. The company also develops IL-17 oral peptide antagonist PN-88,1 an oral metabolic/obesity peptide program, and an oral hepcidin mimetic/ferroportin blocker that is in pre-clinical stage. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California. Show more

7707 Gateway Boulevard, Newark, CA, 94560, United States

https://www.protagonist-inc.com

Biotechnology

Healthcare

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Market Cap

5.413B

52 Wk Range

$33.70 - $96.54

Previous Close

$86.59

Open

$86.72

Volume

668,518

Day Range

$86.00 - $89.55

Enterprise Value

3.483B

Cash

576.1M

Avg Qtr Burn

-1.937M

Insider Ownership

1.71%

Institutional Own.

Qtr Updated

09/30/25

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Drug & Indication	Stage & Event	Catalyst Date
Icotrokinra (JNJ-2113) (PN-235) Details Psoriasis	NDA Acceptance for review	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Rusfertide (PTG-300) Details Polycythemia vera	NDA Acceptance for review	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Icotrokinra (JNJ-2113, formerly PN-235) Details Ulcerative colitis	Phase 2b Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
PN-881 (IL-17 Antagonist) Details Healthy Volunteers	Phase 1 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
PN-477 Details Obesity	Phase 1 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
PN-943 (α4β7-Integrin Antagonist) Details Inflammatory bowel disease, Inflammatory disease	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Rusfertide (PTG-300) (Hepcidin Mimetic) Details Genetic disorder, Rare genetic disease	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
PTG-200 (IL-23R Antagonist) Details Crohns disease, Inflammatory bowel disease, Inflammatory disease	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.