Rapport Therapeutics, Inc., operates as a clinical-stage biopharmaceutical company that focuses on the discovery and development of transformational small molecule medicines for patients suffering from central nervous system (CNS) disorders. The company's lead product candidate is receptor associated protein (RAP)-219, an investigational small molecule that is designed to inhibit TARPy8-containing AMPARs with picomolar affinity for the treatment of focal epilepsy and other CNS disorders, including peripheral neuropathic pain and bipolar disorder. It also develops nicotinic acetylcholine receptor (nAChR) programs, such as a6 nAChR to treat chronic pain and migraine; and a9a10 nAChR for the treatment of hearing/vestibular disorders. The company was formerly known as Precision Neuroscience NewCo, Inc. and changed its name to Rapport Therapeutics, Inc. in October 2022. Rapport Therapeutics, Inc. was incorporated in 2022 and is headquartered in Boston, Massachusetts. Show more

99 High Street, Boston, MA, 02110, United States

Biotechnology

Healthcare

Market Cap

1.327B

52 Wk Range

$7.73 - $42.27

Previous Close

$27.84

Open

$27.93

Volume

223,368

Day Range

$27.53 - $29.08

Enterprise Value

825.7M

Cash

513M

Avg Qtr Burn

-17.47M

Insider Ownership

4.67%

Institutional Own.

Qtr Updated

09/30/25

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Drug & Indication	Stage & Event	Catalyst Date
RAP-219 (Tarpγ8-Specific NAM) Details Primary Generalized Tonic-Clonic Seizures	Phase 3 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
RAP-219 Details Refractory focal epilepsy (drug-resistant focal onset seizures)	Phase 3 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
RAP-219 Details Bipolar mania	Phase 2a Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
RAP-219 (Tarpγ8-Specific NAM) Details Diabetic Peripheral Neuropathic Pain	IND Acceptance decision	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.