Silence Therapeutics plc, a biotechnology company, engages in the discovery and development of novel molecules incorporating short interfering ribonucleic acid (siRNA) to inhibit the expression of specific target genes in hematology, cardiovascular, and rare diseases. The company develops Divesiran (SLN124), which is in Phase 2 development for polycythemia vera, and SLN548 for complement-mediated renal diseases. It also develops Zerlasiran (SLN360) for cardiovascular disease associated with elevated lipoprotein(a); SLN312 for dyslipidemia; SLN365 for hypercholesterolemia; and SLN098 for obesity. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc was incorporated in 1994 and is headquartered in London, United Kingdom. Show more

12 Hammersmith Grove, London, W6 7AP, United Kingdom

Biotechnology

Healthcare

Market Cap

842.2M

52 Wk Range

$4.19 - $17.58

Previous Close

$13.55

Open

$13.38

Volume

682,632

Day Range

$13.04 - $13.81

Enterprise Value

953.6M

Cash

72.05M

Avg Qtr Burn

N/A

Insider Ownership

7.97%

Institutional Own.

39.68%

Qtr Updated

06/30/26

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Drug & Indication	Stage & Event	Catalyst Date
Zerlasiran (SLN360) (siRNA Inhibitor) Details Cardiovascular Disease Due To High Lp(a)	Phase 3 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Divesiran Details Polycythemia Vera	Phase 3 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
SLN312 (ANGPTL3 Inhibitor) Details Dyslipidemia	Phase 1 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
SLN365 (GPR146 Silencer) Details Dyslipidemia	IND Submission	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
SLN098 (INHBE Silencer) Details Obesity	IND Submission	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.