Tango Therapeutics, Inc., a precision oncology company, focuses on the discovery and development of drugs in defined patient populations with unmet medical need. The company develops methylthioadenosine -cooperative protein arginine methyltransferase 5 (PRMT5) inhibitors, including TNG462, which is in Phase 1/2 clinical trial for treating pancreatic and lung cancer; and TNG456, a brain-penetrant PRMT5 inhibitor for the treatment of glioblastoma. It is developing TNG260, a co-repressor of repressor element-1 silencing transcription inhibitor to reverse the immune evasion effect of serine-threonine kinase (STK) 11 loss-of-function mutations to treat lung cancer. The company was founded in 2017 and is headquartered in Boston, Massachusetts. Show more

201 Brookline Avenue, Boston, MA, 02215, United States

Biotechnology

Healthcare

Market Cap

2.469B

52 Wk Range

$1.03 - $17.63

Previous Close

$17.30

Open

$17.33

Volume

2,861,457

Day Range

$17.25 - $18.50

Enterprise Value

2.162B

Cash

343.1M

Avg Qtr Burn

-29.72M

Insider Ownership

1.28%

Institutional Own.

Qtr Updated

12/31/25

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Drug & Indication	Stage & Event	Catalyst Date
TNG456 Details Glioblastoma	Phase 1/2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Vopimetostat (TNG462) Details Pancreatic, lung, MTAP-deleted cancers	Phase 1/2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
TNG260 + pembrolizumab Details Lung cancer	Phase 1/2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
TNG908 Details Glioblastoma	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
TNG348 Details Cancer, Ovarian cancer, Breast cancer, Prostate cancer, Pancreatic cancer	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.