ZYME - Zymeworks

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Zymeworks NASDAQ:ZYME Zymeworks is a clinical-stage biopharmaceutical company dedicated to the development of next-generation multifunctional biotherapeutics. Zymeworks' suite of therapeutic platforms and its fully integrated drug development engine enable precise engineering of highly differentiated product candidates. Zymeworks' lead clinical candidate, zanidatamab (ZW25), is a novel Azymetric™ bispecific antibody which has been granted Breakthrough Therapy designation by the FDA and is currently enrolling in a pivotal clinical trial for refractory HER2-amplified biliary tract cancer (HERIZON-BTC-01) as well as several Phase 2 clinical trials for HER2-expressing gastroesophageal and breast cancers. Zymeworks' second clinical candidate, ZW49, is a novel bispecific HER2-targeting antibody-drug conjugate currently in Phase 1 clinical development and combines the unique design and antibody framework of zanidatamab with Zymeworks' proprietary ZymeLink™ linker and cytotoxin. Zymeworks is also advancing a deep preclinical pipeline in oncology (including immuno-oncology agents) and other therapeutic areas. In addition, its therapeutic platforms are being leveraged through strategic partnerships with nine biopharmaceutical companies.

Location: 1385 8th Ave W Suite 540, British Columbia, V6H 3V9, Canada | Website: www.zymeworks.com | Industry: Pharmaceutical Preparation Manufacturing | Sector: Manufacturing


Market Cap

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52 Wk Range

$ - $

Previous Close

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Open

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Day Range

N/A - N/A

Volume

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Avg Volume

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Enterprise Value

714.2M

Cash

297.2M

Avg Qtr Burn

-13.65M

Short % of Float

10.96%

Insider Ownership

0.17%

Institutional Own.

-

Qtr Updated

09/30/24


Drug Pipeline

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Drug & IndicationStage & EventCatalyst Date
Ziihera® (zanidatamab-hrii) Details
Cancer, Solid tumor/s, Biliary Tract Cancer

Approved

Quarterly sales

Zanidatamab + Chemo/trastuzumab Details
Breast cancer, Cancer, HER2-expressing cancers

Phase 3

Initiation

Zanidatamab (HER2) + chemotherapy + tislelizumab Details
Cancer, Gastroesophageal adenocarcinomas, Cholangiocarcinoma

Phase 2

Update

Zanidatamab zovodotin (ZW49) Details
HER2-expressing cancers, Cancer, Non-small cell lung carcinoma

Phase 2

Update

Phase 1/2

Data readout

ZW191 Details
Cancer, Solid tumor/s

Phase 1

Data readout

ZW171 Details
Cancer, Mesothelin-expressing solid tumors

Phase 1

Data readout

IND

Submission

IND

Submission