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ALX Oncology Holdings Inc NasdaqGS:ALXO ALX Oncology Holdings Inc., a clinical-stage immuno-oncology company, focuses on developing therapies for cancer patients in the United States. The company's lead product candidate is Evorpacept, a CD47 blocking therapeutic biologic in development as a combination therapy with other anti-cancer agents, including ASPEN-06, under Phase 2 clinical study for treating Gastric/GEJ cancer; ASPEN-07, under Phase 1 clinical study for treating urothelial cancer; and ASPEN-03 and ASPEN-04, both under Phase 2 clinical study for treating head and neck squamous cell carcinoma. It has collaboration agreement for Evorpacept combination programs comprising Jazz Pharmaceuticals plc for zanidatamab, under Phase 1 trial for the treatment of breast cancer and other solid tumors; Quantum Leap Healthcare collaborative with an ADC, fam-trastuzumab deruxtecan-nxki, under Phase 1 trial for the treatment of patients with breast cancer; MD Anderson Cancer Center with rituximab and lenalidomide for the treatment of patients with indolent and aggressive NHL; Sanofi with isatuximab and dexamethasone, under Phase 1/2 trial for the treatment of patients with relapsed or refractory multiple myeloma; Academic Gastrointestinal Cancer Symposium; and University of Pittsburgh with liposomal doxorubicin and pembrolizumab, under Phase 2 trial recurrent platinum-resistant ovarian cancer. In addition, the company has collaboration agreement with Tallac Therapeutics, Inc. for the development of ALTA-002, a potent immune activator targeted to myeloid cells in the tumor to promote innate and adaptive anti-cancer immune responses. It has license agreements with Board of Trustees of the Leland Stanford Junior University, Selexis SA, and Crystal Bioscience, Inc. The company was incorporated in 2015 and is headquartered in South San Francisco, California.
Location: 323 Allerton Avenue, South San Francisco, CA, 94080, United States | Website: https://www.alxoncology.com | Industry: Biotechnology | Sector: Healthcare
Market Cap
NaN
52 Wk Range
$ - $
Previous Close
$N/A
Open
$N/A
Day Range
N/A - N/A
Volume
N/A
Avg Volume
N/A
Enterprise Value
-56.28M
Cash
97.83M
Avg Qtr Burn
-27.16M
Short % of Float
18.59%
Insider Ownership
2.45%
Institutional Own.
79.81%
Qtr Updated
03/31/25
Drug Pipeline
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Drug & Indication | Stage & Event | Catalyst Date |
---|---|---|
Phase 2 Data readout | ||
Evorpacept (ALX148) + Keytruda Details Cancer, Platinum-resistant ovarian cancer | Phase 2 Data readout | |
Evorpacept + cetuximab + pembrolizumab Details Cancer, Metastatic colorectal cancer | Phase 2 Update | |
Evorpacept (ALX148) + Herceptin® (trastuzumab)+Cyramza® (ramucirumab) and paclitaxel Details Cancer, Gastric cancer | Phase 2 Update | |
Evorpacept (ALX148) + rituximab and lenalidomide Details Non-Hodgkin lymphoma | Phase 1/2 Data readout | |
Evorpacept (ALX148) + Sarclisa Details Cancer, Multiple myeloma | Phase 1/2 Data readout | |
Evorpacept (ALX148) + Zanidatamab Details Breast cancer, Cancer | Phase 1/2 Update | |
Evorpacept (ALX148) + ENHERTU® Details Breast cancer, Cancer | Phase 1 Data readout | |
Evorpacept + enfortumab vedotin-ejfv/PADCEV® Details Cancer, Urothelial cancer | Phase 1 Data readout | |
ALX2004 Details EGFR-expressing solid tumors | Phase 1 Initiation | |
Evorpacept (ALX148) + Venetoclax Details Cancer, Acute myeloid leukemia | Failed Discontinued | |
Evorpacept (ALX148) combo w/ azacitidine Details Myelodysplastic syndrome, Cancer | Failed Discontinued |