Xilio Therapeutics, Inc., a clinical-stage biotechnology company, engages in the discovery and development of tumor-activated immuno-oncology therapies. The company's checkpoint inhibitor program includes XTX101, an investigational Fc-enhanced, tumor-activated anti-CTLA-4 mAb that is in Phase 2 clinical trial for patients with advanced solid tumors. It also develops cytokine programs, which comprises XTX202, a tumor-activated beta-gamma biased IL-2, currently under Phase 2 clinal trials; and XTX301, an investigational tumor-activated, engineered IL-12 molecule, currently under Phase 1 studies. The company was founded in 2016 and is headquartered in Waltham, Massachusetts. Show more

Location: 828 Winter Street, Waltham, MA, 02451, United States | Website: https://xiliotx.com | Industry: Biotechnology | Sector: Healthcare

Market Cap

39.53M

52 Wk Range

$0.61 - $1.70

Previous Close

$0.75

Open

$0.75

Volume

198,188

Day Range

$0.74 - $0.76

Enterprise Value

-56.67M

Cash

103.8M

Avg Qtr Burn

-4.288M

Insider Ownership

45.12%

Institutional Own.

21.72%

Qtr Updated

09/30/25

Drug Pipeline

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Drug & Indication	Stage & Event	Catalyst Date
Efarindodekin Alfa (XTX301) Details Solid tumor/s	Phase 2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Vilastobart (XTX101)+ atezolizumab Details Metastatic microsatellite stable colorectal cancer (MSS CRC)	Phase 1/2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
XTX501 Details Solid tumor/s	IND Submission	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
XTX202 (monotherapy) Details Renal cell carcinoma, Melanoma	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.